Meaning, Origin & Family History (2025)

Table of Contents
The meaning of Hiner How common is the last name Hiner in the United States? Race and Ethnicity of people with the last name Hiner Hiner ancestry composition Possible origins of the surname Hiner What Hiner haplogroups can tell you Your paternal lineage may be linked to Ötzi the Iceman Your maternal lineage may be linked to Marie Antoinette What do people with the surname Hiner have in common? Preferences Chocolate Ice Cream Vanilla Ice Cream Stawberry Ice Cream Likes Hoppy Beer Chocolate Ice Cream Vanilla Ice Cream Stawberry Ice Cream Likes Hoppy Beer Chocolate Ice Cream Vanilla Ice Cream Stawberry Ice Cream Likes Hoppy Beer Traits Misophonia Cheek Dimples Acrophobia Misophonia Cheek Dimples Acrophobia Misophonia Cheek Dimples Acrophobia Habits Vitamin Use Kinesthetic Learner Tea Consumption Verbal Learner Vitamin Use Kinesthetic Learner Tea Consumption Verbal Learner Vitamin Use Kinesthetic Learner Tea Consumption Verbal Learner Wellness Migraine Cat Allergy Migraine Cat Allergy Migraine Cat Allergy Are health conditions linked to the last name Hiner? Age-Related Macular Degeneration Hereditary Hemochromatosis (HFE-Related) Late-Onset Alzheimer's Disease Celiac Disease Celiac Disease Hereditary Hemochromatosis (HFE-Related) Alpha-1 Antitrypsin Deficiency Hereditary Thrombophilia Alpha-1 Antitrypsin Deficiency Cystic Fibrosis Age-Related Macular Degeneration Hereditary Hemochromatosis (HFE-Related) Late-Onset Alzheimer's Disease Celiac Disease Celiac Disease Hereditary Hemochromatosis (HFE-Related) Alpha-1 Antitrypsin Deficiency Hereditary Thrombophilia Alpha-1 Antitrypsin Deficiency Cystic Fibrosis Age-Related Macular Degeneration Hereditary Hemochromatosis (HFE-Related) Late-Onset Alzheimer's Disease Celiac Disease Celiac Disease Hereditary Hemochromatosis (HFE-Related) Alpha-1 Antitrypsin Deficiency Hereditary Thrombophilia Alpha-1 Antitrypsin Deficiency Cystic Fibrosis

The meaning of Hiner

1. English (Cambridgeshire): possibly an occupational name for an agricultural laborer, a variant of Hine with the addition of the Middle English agent suffix -er. 2. Americanized form of German Heiner.

Dictionary of American Family Names, 2nd edition, © Oxford University Press, 2022.

How common is the last name Hiner in the United States?

The surname Hiner, according to the Decennial U.S. Census data, saw a slight decrease in popularity between 2000 and 2010. In 2000, it was ranked as the 9,249th most common name, but by 2010, it had fallen slightly to the 9,590th position, marking a 3.69% drop. Despite this fall in rank, the actual count of people with the Hiner surname increased by 4.57%, from 3,242 in 2000 to 3,390 in 2010. Consequently, the proportion of people named Hiner per 100,000 population also decreased by 4.17%.

20002010Change
Rank#9,249#9,590-3.69%
Count3,2423,3904.57%
Proportion per 100k1.21.15-4.17%

Race and Ethnicity of people with the last name Hiner

In terms of ethnicity, the Decennial U.S. Census data shows that the majority of individuals with the Hiner surname identified as White, although this percentage slightly dropped from 92.60% in 2000 to 90.97% in 2010. The percentage of those identifying as Black and Hispanic grew, with an increase of 17.09% and 62.76%, respectively. The American Indian and Alaskan Native category also experienced growth, increasing by 56.18%. However, the percentage of people with the Hiner surname who identified as Asian/Pacific Islander or of Two or more races decreased by 9.62% and 11.17%, respectively.

20002010Change
White92.6%90.97%-1.76%
Black2.75%3.22%17.09%
Hispanic1.45%2.36%62.76%
Two or More Races1.79%1.59%-11.17%
American Indian and Alaskan Native0.89%1.39%56.18%
Asian/Pacific Islander0.52%0.47%-9.62%

Hiner ancestry composition

23andMe computes an ancestry breakdown for each customer. People may have ancestry from just one population or they may have ancestry from several populations. The most commonly-observed ancestry found in people with the surname Hiner is British & Irish, which comprises 44.6% of all ancestry found in people with the surname. The next two most common ancestries are French & German (31.9%) and Scandinavian (6.2%). Additional ancestries include Eastern European, Italian, Spanish & Portuguese, Greek & Balkan, and Ashkenazi Jewish.

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ANCESTRY BREAKDOWNCOMPOSITION
British & Irish44.6%
French & German31.9%
Scandinavian6.2%
Other17.3%

Meaning, Origin & Family History (1)

Possible origins of the surname Hiner

Your DNA provides clues about where your recent ancestors may have lived. Having many distant relatives in the same location suggests that you may all share common ancestry there. Locations with many distant relatives can also be places where people have migrated recently, such as large cities. If a large number of individuals who share your surname have distant relatives in a specific area, it could indicate a connection between your surname and that location, stemming from either recent ancestral ties or migration.

Based on 23andMe data, people with last name Hiner have recent ancestry locations in the United Kingdom of Great Britain and Northern Ireland and Ireland.

RECENT ANCESTRY LocationPercentage
Greater London, United Kingdom88.20%
West Yorkshire, United Kingdom88.20%
Greater Manchester, United Kingdom88.20%
Tyne And Wear, United Kingdom88.20%
Glasgow City, United Kingdom88.20%

What Hiner haplogroups can tell you

Haplogroups are genetic population groups that share a common ancestor on either your paternal or maternal line. These paternal and maternal haplogroups shed light on your genetic ancestry and help tell the story of your family.

The top paternal haplogroup of people with the surname Hiner is G-Z39088, which is predominantly found among people with European ancestry. Haplogroup G-Z39088 is descended from haplogroup G-M201. Other common haplogroups include R-L20 and J-M241, which are predominantly found among people with European and European ancestry. Other surnames with similar common haplogroups are: Waldron, Champion, Love, Britton, Keene, Manning, Milner, Sylvester, Morris, Derr.

The most common maternal haplogroups of people with Hiner surname are: H1, H, U5a. These most commonly trace back to individuals of European ancestry.

Meaning, Origin & Family History (2)Paternal Haplogroup Origins G-M201

Meaning, Origin & Family History (3)

Your paternal lineage may be linked to Ötzi the Iceman

Ötzi the Iceman was discovered in 1991, protruding from a snow-bank high in the Alps near the Austrian-Italian border. His 5,300-year-old remains turned out to be so well preserved that researchers were able to construct a detailed account of his life and death. Chemical analysis of Ötzi's teeth indicates he came from the Italian side of the Alps. He had suffered during the year before his death with whipworm, a stomach parasite that was found in his digestive tract. Yet he was fit enough to climb 6,500 feet in elevation during the day or two before he met his end in a rocky alpine hollow. Ötzi apparently was murdered, struck by a stone arrow point that was found lodged in his left shoulder. The twisted position of his body indicates that the murderer, or one of his accomplices, pulled the arrow's shaft out of Ötzi's prone body.Yet whoever killed Ötzi did not take the valuable and finely wrought copper axe that he carried with him — an indicator that at the age of 45, the Ice Man may have been a figure of some importance in his community. Recently, scientists who were able to extract DNA from Ötzi's remains discovered that he belonged to a paternal lineage that stems from haplogroup G-M201. Today, Ötzi's lineage reaches its highest levels in Sardinia and Corsica, and was once common among early European farmers.

Your maternal lineage may be linked to Marie Antoinette

Because it is so dominant in the general European population, haplogroup H also appears quite frequently in the continent's royal houses. Marie Antoinette, an Austrian Hapsburg who married into the French royal family, inherited the haplogroup from her maternal ancestors. So did Prince Philip, Duke of Edinburgh, whose recorded genealogy traces his female line to Bavaria. Scientists also discovered that famed 16th century astronomer Nicolaus Copernicus traced his maternal lineages to haplogroup H.

Meaning, Origin & Family History (4)

What do people with the surname Hiner have in common?

Spoiler alert: it's complicated. People with the same last name are usually no more genetically similar than a randomly sampled group of people from the same population. That said, people with the same surname are more likely to have similar ancestries than randomly sampled individuals. The reason is the tendency of people with similar cultural or geographical backgrounds to preferentially mate with one another. That's why people who share a surname may be more likely to share traits and tendencies in common than people within the general population. Check out the percentages below to see the prevalences of tastes, habits, and traits of people with your surname compared with prevalences among 23andMe users.

Preferences

Meaning, Origin & Family History (5)

Chocolate Ice Cream

Prefers chocolate flavored ice cream over other flavors.

"Hiner" Surname 33.3%

23andMe Users 41.3%

Meaning, Origin & Family History (6)

Vanilla Ice Cream

Prefers vanilla flavored ice cream over other flavors.

"Hiner" Surname 39.4%

23andMe Users 36.7%

Meaning, Origin & Family History (7)

Stawberry Ice Cream

Prefers strawberry flavored ice cream over other flavors.

"Hiner" Surname 21.2%

23andMe Users 14.7%

Meaning, Origin & Family History (8)

Likes Hoppy Beer

Like beer that has a strong hop flavor and aroma.

"Hiner" Surname 23.8%

23andMe Users 20.0%

Meaning, Origin & Family History (9)

Chocolate Ice Cream

Prefers chocolate flavored ice cream over other flavors.

"Hiner" Surname 33.3%

23andMe Users 41.3%

Meaning, Origin & Family History (10)

Vanilla Ice Cream

Prefers vanilla flavored ice cream over other flavors.

"Hiner" Surname 39.4%

23andMe Users 36.7%

Meaning, Origin & Family History (11)

Stawberry Ice Cream

Prefers strawberry flavored ice cream over other flavors.

"Hiner" Surname 21.2%

23andMe Users 14.7%

Meaning, Origin & Family History (12)

Likes Hoppy Beer

Like beer that has a strong hop flavor and aroma.

"Hiner" Surname 23.8%

23andMe Users 20.0%

Meaning, Origin & Family History (13)

Chocolate Ice Cream

Prefers chocolate flavored ice cream over other flavors.

"Hiner" Surname 33.3%

23andMe Users 41.3%

Meaning, Origin & Family History (14)

Vanilla Ice Cream

Prefers vanilla flavored ice cream over other flavors.

"Hiner" Surname 39.4%

23andMe Users 36.7%

Meaning, Origin & Family History (15)

Stawberry Ice Cream

Prefers strawberry flavored ice cream over other flavors.

"Hiner" Surname 21.2%

23andMe Users 14.7%

Meaning, Origin & Family History (16)

Likes Hoppy Beer

Like beer that has a strong hop flavor and aroma.

"Hiner" Surname 23.8%

23andMe Users 20.0%

Traits

Meaning, Origin & Family History (17)

Misophonia

When sounds made by others, like the sound of chewing or yawning, provoke strong emotional reactions in an individual.

"Hiner" Surname 28.0%

23andMe Users 27.9%

Meaning, Origin & Family History (18)

Cheek Dimples

Small indentations that appear on the cheeks when a person smiles.

"Hiner" Surname 47.4%

23andMe Users 37.6%

Meaning, Origin & Family History (19)

Acrophobia

An intense fear of heights that goes beyond the concern many people feel around significant heights.

"Hiner" Surname 27.6%

23andMe Users 16.7%

Meaning, Origin & Family History (20)

Misophonia

When sounds made by others, like the sound of chewing or yawning, provoke strong emotional reactions in an individual.

"Hiner" Surname 28.0%

23andMe Users 27.9%

Meaning, Origin & Family History (21)

Cheek Dimples

Small indentations that appear on the cheeks when a person smiles.

"Hiner" Surname 47.4%

23andMe Users 37.6%

Meaning, Origin & Family History (22)

Acrophobia

An intense fear of heights that goes beyond the concern many people feel around significant heights.

"Hiner" Surname 27.6%

23andMe Users 16.7%

Meaning, Origin & Family History (23)

Misophonia

When sounds made by others, like the sound of chewing or yawning, provoke strong emotional reactions in an individual.

"Hiner" Surname 28.0%

23andMe Users 27.9%

Meaning, Origin & Family History (24)

Cheek Dimples

Small indentations that appear on the cheeks when a person smiles.

"Hiner" Surname 47.4%

23andMe Users 37.6%

Meaning, Origin & Family History (25)

Acrophobia

An intense fear of heights that goes beyond the concern many people feel around significant heights.

"Hiner" Surname 27.6%

23andMe Users 16.7%

Habits

Meaning, Origin & Family History (26)

Vitamin Use

Takes vitamins on a regular basis.

"Hiner" Surname 42.9%

23andMe Users 45.5%

Meaning, Origin & Family History (27)

Kinesthetic Learner

Preferring to learn and process information through hands-on activities, practical experiences, and active engagement.

"Hiner" Surname 47.4%

23andMe Users 61.5%

Meaning, Origin & Family History (28)

Tea Consumption

A preference for drinking caffeinated tea in a particular week.

"Hiner" Surname 50.0%

23andMe Users 49.2%

Meaning, Origin & Family History (29)

Verbal Learner

Preferring to learn and process information through words, both written and spoken.

"Hiner" Surname 47.4%

23andMe Users 22.9%

Meaning, Origin & Family History (30)

Vitamin Use

Takes vitamins on a regular basis.

"Hiner" Surname 42.9%

23andMe Users 45.5%

Meaning, Origin & Family History (31)

Kinesthetic Learner

Preferring to learn and process information through hands-on activities, practical experiences, and active engagement.

"Hiner" Surname 47.4%

23andMe Users 61.5%

Meaning, Origin & Family History (32)

Tea Consumption

A preference for drinking caffeinated tea in a particular week.

"Hiner" Surname 50.0%

23andMe Users 49.2%

Meaning, Origin & Family History (33)

Verbal Learner

Preferring to learn and process information through words, both written and spoken.

"Hiner" Surname 47.4%

23andMe Users 22.9%

Meaning, Origin & Family History (34)

Vitamin Use

Takes vitamins on a regular basis.

"Hiner" Surname 42.9%

23andMe Users 45.5%

Meaning, Origin & Family History (35)

Kinesthetic Learner

Preferring to learn and process information through hands-on activities, practical experiences, and active engagement.

"Hiner" Surname 47.4%

23andMe Users 61.5%

Meaning, Origin & Family History (36)

Tea Consumption

A preference for drinking caffeinated tea in a particular week.

"Hiner" Surname 50.0%

23andMe Users 49.2%

Meaning, Origin & Family History (37)

Verbal Learner

Preferring to learn and process information through words, both written and spoken.

"Hiner" Surname 47.4%

23andMe Users 22.9%

Wellness

Meaning, Origin & Family History (38)

Migraine

A severe headache characterized by intense pain, sensitivity to light and sound, and often accompanied by nausea and vomiting.

"Hiner" Surname 14.1%

23andMe Users 16.4%

Meaning, Origin & Family History (39)

Cat Allergy

An allergic reaction to cats, characterized by symptoms such as sneezing, itching, and difficulty breathing.

"Hiner" Surname 53.8%

23andMe Users 36.7%

Meaning, Origin & Family History (40)

Migraine

A severe headache characterized by intense pain, sensitivity to light and sound, and often accompanied by nausea and vomiting.

"Hiner" Surname 14.1%

23andMe Users 16.4%

Meaning, Origin & Family History (41)

Cat Allergy

An allergic reaction to cats, characterized by symptoms such as sneezing, itching, and difficulty breathing.

"Hiner" Surname 53.8%

23andMe Users 36.7%

Meaning, Origin & Family History (42)

Migraine

A severe headache characterized by intense pain, sensitivity to light and sound, and often accompanied by nausea and vomiting.

"Hiner" Surname 14.1%

23andMe Users 16.4%

Meaning, Origin & Family History (43)

Cat Allergy

An allergic reaction to cats, characterized by symptoms such as sneezing, itching, and difficulty breathing.

"Hiner" Surname 53.8%

23andMe Users 36.7%

Are health conditions linked to the last name Hiner?

The short answer is that, if there is an association between surname and health, it's usually more about your ancestry than your name. Individuals with a given surname are no more genetically similar than the general population but often have similar ancestries. The populations of people associated with those shared ancestries often have sets of genetic variations, also known as alleles, in common. Some of those alleles are associated with a greater likelihood of developing certain diseases.

Disease variant frequency by ancestry

Disease allele frequencies in populations associated with the surname Hiner are shown below. Important Note: not everyone with a disease allele will develop these health condition

Age-Related Macular Degeneration

Y402H variant

Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss among older adults. The disease results in damage to the central part of the retina (the macula), impairing vision needed for reading, driving, or even recognizing faces. The 23andMe Health + Ancestry DNA test includes the two most common variants associated with an increased risk of developing the condition: the Y402H variant in the CFH gene and the A69S variant in the ARMS2 gene. Learn more about Age-Related Macular Degeneration

British & Irish 62.1%

23andMe Users 57.2%

Hereditary Hemochromatosis (HFE-Related)

H63D variant

Hereditary hemochromatosis is a genetic condition characterized by absorption of too much dietary iron. This may lead to iron overload, which can cause damage to the joints and certain organs, such as the liver, skin, heart, and pancreas. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to this condition. Learn more about Hereditary Hemochromatosis (HFE-Related)

British & Irish 28.3%

23andMe Users 25.0%

Late-Onset Alzheimer's Disease

ε4 variant

Alzheimer's disease is characterized by memory loss, cognitive decline, and personality changes. Late-onset Alzheimer's disease is the most common form of Alzheimer's disease, developing after age 65. Many factors, including genetics, can influence a person's chances of developing the condition. The 23andMe Health + Ancestry DNA test includes the most common genetic variant associated with late-onset Alzheimer's disease: the ε4 variant in the APOE gene. Learn more about Late-Onset Alzheimer's Disease

British & Irish 28.2%

23andMe Users 25.5%

Celiac Disease

HLA-DQ2.5 variant

Celiac disease is an autoimmune condition in which the consumption of gluten (found in wheat, barley, and rye) can result in damage to the small intestine. Celiac disease can lead to both digestive and non-digestive problems. The 23andMe Health + Ancestry DNA test includes two common variants associated with an increased risk of developing this condition. Learn more about Celiac Disease

British & Irish 27.7%

23andMe Users 21.4%

Celiac Disease

HLA-DQ8 variant

Celiac disease is an autoimmune condition in which the consumption of gluten (found in wheat, barley, and rye) can result in damage to the small intestine. Celiac disease can lead to both digestive and non-digestive problems. The 23andMe Health + Ancestry DNA test includes two common variants associated with an increased risk of developing this condition. Learn more about Celiac Disease

British & Irish 18.9%

23andMe Users 20.0%

Hereditary Hemochromatosis (HFE-Related)

C282Y variant

Hereditary hemochromatosis is a genetic condition characterized by absorption of too much dietary iron. This may lead to iron overload, which can cause damage to the joints and certain organs, such as the liver, skin, heart, and pancreas. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to this condition. Learn more about Hereditary Hemochromatosis (HFE-Related)

British & Irish 17.6%

23andMe Users 9.8%

Alpha-1 Antitrypsin Deficiency

PI*S variant

AAT deficiency is a genetic condition that can lead to lung and liver disease. It is caused by decreased levels of the alpha-1 antitrypsin (AAT) protein. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to this deficiency: the PI*S and PI*Z variants in the SERPINA1 gene. Learn more about Alpha-1 Antitrypsin Deficiency

British & Irish 9.5%

23andMe Users 7.3%

Hereditary Thrombophilia

Factor V Leiden variant

Hereditary thrombophilia is a predisposition to developing harmful blood clots. These harmful blood clots most commonly form in the legs and can travel to the lungs. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to hereditary thrombophilia. Learn more about Hereditary Thrombophilia

British & Irish 4.2%

23andMe Users 4.5%

Alpha-1 Antitrypsin Deficiency

PI*Z variant

AAT deficiency is a genetic condition that can lead to lung and liver disease. It is caused by decreased levels of the alpha-1 antitrypsin (AAT) protein. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to this deficiency: the PI*S and PI*Z variants in the SERPINA1 gene. Learn more about Alpha-1 Antitrypsin Deficiency

British & Irish 4.0%

23andMe Users 2.9%

Cystic Fibrosis

DeltaF508 variant

Cystic fibrosis is a rare genetic disorder characterized by impaired lung and digestive function. A person must have two variants in the CFTR gene in order to have this condition. Learn more about Cystic Fibrosis

British & Irish 3.5%

23andMe Users 2.3%

Age-Related Macular Degeneration

Y402H variant

Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss among older adults. The disease results in damage to the central part of the retina (the macula), impairing vision needed for reading, driving, or even recognizing faces. The 23andMe Health + Ancestry DNA test includes the two most common variants associated with an increased risk of developing the condition: the Y402H variant in the CFH gene and the A69S variant in the ARMS2 gene. Learn more about Age-Related Macular Degeneration

British & Irish 62.1%

23andMe Users 57.2%

Hereditary Hemochromatosis (HFE-Related)

H63D variant

Hereditary hemochromatosis is a genetic condition characterized by absorption of too much dietary iron. This may lead to iron overload, which can cause damage to the joints and certain organs, such as the liver, skin, heart, and pancreas. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to this condition. Learn more about Hereditary Hemochromatosis (HFE-Related)

British & Irish 28.3%

23andMe Users 25.0%

Late-Onset Alzheimer's Disease

ε4 variant

Alzheimer's disease is characterized by memory loss, cognitive decline, and personality changes. Late-onset Alzheimer's disease is the most common form of Alzheimer's disease, developing after age 65. Many factors, including genetics, can influence a person's chances of developing the condition. The 23andMe Health + Ancestry DNA test includes the most common genetic variant associated with late-onset Alzheimer's disease: the ε4 variant in the APOE gene. Learn more about Late-Onset Alzheimer's Disease

British & Irish 28.2%

23andMe Users 25.5%

Celiac Disease

HLA-DQ2.5 variant

Celiac disease is an autoimmune condition in which the consumption of gluten (found in wheat, barley, and rye) can result in damage to the small intestine. Celiac disease can lead to both digestive and non-digestive problems. The 23andMe Health + Ancestry DNA test includes two common variants associated with an increased risk of developing this condition. Learn more about Celiac Disease

British & Irish 27.7%

23andMe Users 21.4%

Celiac Disease

HLA-DQ8 variant

Celiac disease is an autoimmune condition in which the consumption of gluten (found in wheat, barley, and rye) can result in damage to the small intestine. Celiac disease can lead to both digestive and non-digestive problems. The 23andMe Health + Ancestry DNA test includes two common variants associated with an increased risk of developing this condition. Learn more about Celiac Disease

British & Irish 18.9%

23andMe Users 20.0%

Hereditary Hemochromatosis (HFE-Related)

C282Y variant

Hereditary hemochromatosis is a genetic condition characterized by absorption of too much dietary iron. This may lead to iron overload, which can cause damage to the joints and certain organs, such as the liver, skin, heart, and pancreas. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to this condition. Learn more about Hereditary Hemochromatosis (HFE-Related)

British & Irish 17.6%

23andMe Users 9.8%

Alpha-1 Antitrypsin Deficiency

PI*S variant

AAT deficiency is a genetic condition that can lead to lung and liver disease. It is caused by decreased levels of the alpha-1 antitrypsin (AAT) protein. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to this deficiency: the PI*S and PI*Z variants in the SERPINA1 gene. Learn more about Alpha-1 Antitrypsin Deficiency

British & Irish 9.5%

23andMe Users 7.3%

Hereditary Thrombophilia

Factor V Leiden variant

Hereditary thrombophilia is a predisposition to developing harmful blood clots. These harmful blood clots most commonly form in the legs and can travel to the lungs. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to hereditary thrombophilia. Learn more about Hereditary Thrombophilia

British & Irish 4.2%

23andMe Users 4.5%

Alpha-1 Antitrypsin Deficiency

PI*Z variant

AAT deficiency is a genetic condition that can lead to lung and liver disease. It is caused by decreased levels of the alpha-1 antitrypsin (AAT) protein. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to this deficiency: the PI*S and PI*Z variants in the SERPINA1 gene. Learn more about Alpha-1 Antitrypsin Deficiency

British & Irish 4.0%

23andMe Users 2.9%

Cystic Fibrosis

DeltaF508 variant

Cystic fibrosis is a rare genetic disorder characterized by impaired lung and digestive function. A person must have two variants in the CFTR gene in order to have this condition. Learn more about Cystic Fibrosis

British & Irish 3.5%

23andMe Users 2.3%

Age-Related Macular Degeneration

Y402H variant

Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss among older adults. The disease results in damage to the central part of the retina (the macula), impairing vision needed for reading, driving, or even recognizing faces. The 23andMe Health + Ancestry DNA test includes the two most common variants associated with an increased risk of developing the condition: the Y402H variant in the CFH gene and the A69S variant in the ARMS2 gene. Learn more about Age-Related Macular Degeneration

British & Irish 62.1%

23andMe Users 57.2%

Hereditary Hemochromatosis (HFE-Related)

H63D variant

Hereditary hemochromatosis is a genetic condition characterized by absorption of too much dietary iron. This may lead to iron overload, which can cause damage to the joints and certain organs, such as the liver, skin, heart, and pancreas. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to this condition. Learn more about Hereditary Hemochromatosis (HFE-Related)

British & Irish 28.3%

23andMe Users 25.0%

Late-Onset Alzheimer's Disease

ε4 variant

Alzheimer's disease is characterized by memory loss, cognitive decline, and personality changes. Late-onset Alzheimer's disease is the most common form of Alzheimer's disease, developing after age 65. Many factors, including genetics, can influence a person's chances of developing the condition. The 23andMe Health + Ancestry DNA test includes the most common genetic variant associated with late-onset Alzheimer's disease: the ε4 variant in the APOE gene. Learn more about Late-Onset Alzheimer's Disease

British & Irish 28.2%

23andMe Users 25.5%

Celiac Disease

HLA-DQ2.5 variant

Celiac disease is an autoimmune condition in which the consumption of gluten (found in wheat, barley, and rye) can result in damage to the small intestine. Celiac disease can lead to both digestive and non-digestive problems. The 23andMe Health + Ancestry DNA test includes two common variants associated with an increased risk of developing this condition. Learn more about Celiac Disease

British & Irish 27.7%

23andMe Users 21.4%

Celiac Disease

HLA-DQ8 variant

Celiac disease is an autoimmune condition in which the consumption of gluten (found in wheat, barley, and rye) can result in damage to the small intestine. Celiac disease can lead to both digestive and non-digestive problems. The 23andMe Health + Ancestry DNA test includes two common variants associated with an increased risk of developing this condition. Learn more about Celiac Disease

British & Irish 18.9%

23andMe Users 20.0%

Hereditary Hemochromatosis (HFE-Related)

C282Y variant

Hereditary hemochromatosis is a genetic condition characterized by absorption of too much dietary iron. This may lead to iron overload, which can cause damage to the joints and certain organs, such as the liver, skin, heart, and pancreas. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to this condition. Learn more about Hereditary Hemochromatosis (HFE-Related)

British & Irish 17.6%

23andMe Users 9.8%

Alpha-1 Antitrypsin Deficiency

PI*S variant

AAT deficiency is a genetic condition that can lead to lung and liver disease. It is caused by decreased levels of the alpha-1 antitrypsin (AAT) protein. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to this deficiency: the PI*S and PI*Z variants in the SERPINA1 gene. Learn more about Alpha-1 Antitrypsin Deficiency

British & Irish 9.5%

23andMe Users 7.3%

Hereditary Thrombophilia

Factor V Leiden variant

Hereditary thrombophilia is a predisposition to developing harmful blood clots. These harmful blood clots most commonly form in the legs and can travel to the lungs. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to hereditary thrombophilia. Learn more about Hereditary Thrombophilia

British & Irish 4.2%

23andMe Users 4.5%

Alpha-1 Antitrypsin Deficiency

PI*Z variant

AAT deficiency is a genetic condition that can lead to lung and liver disease. It is caused by decreased levels of the alpha-1 antitrypsin (AAT) protein. The 23andMe Health + Ancestry DNA test includes the two most common variants linked to this deficiency: the PI*S and PI*Z variants in the SERPINA1 gene. Learn more about Alpha-1 Antitrypsin Deficiency

British & Irish 4.0%

23andMe Users 2.9%

Cystic Fibrosis

DeltaF508 variant

Cystic fibrosis is a rare genetic disorder characterized by impaired lung and digestive function. A person must have two variants in the CFTR gene in order to have this condition. Learn more about Cystic Fibrosis

British & Irish 3.5%

23andMe Users 2.3%

Meaning, Origin & Family History (2025)
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